How can academic learning and working spaces be designed in the future? How can post-disciplinary, hybrid and experimental learning and research be promoted through spatial settings? To answer these questions, a ‘spatial laboratory’ has been created over the last two years in the Old Reading Room of the TU Berlin in cooperation with the UdK Berlin. The spatial concept is radically participatory and is based on the independent activity of the users - i.e. students, teachers and researchers from the arts, technology, natural sciences and humanities. In order to meet the very individual needs within learning or research situations, the spatial elements can be combined into a wide variety of constellations as required. Users thus encounter a flexible and customisable space that is designed to support collaborative work and creative thinking. In order to synthesise the findings of recent years and provide systematic insights, a sociological evaluation was also carried out, the results of which will be presented. Disciplinary diversity and multifunctionality place particular demands on the participatory planning, implementation and evaluation of a learning space - therefore, in addition to best practices, potential stumbling blocks and problematic expectations of such learning spaces of the future will also be discussed.